Comfortis® (spinosad) kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis) for one month. Comfortis is safe for use in dogs and puppies 14 weeks of age or older and 3.3 lbs of body weight or greater, and cats and kittens 14 weeks of age or older and 2 pounds of body weight or greater.
Important Safety Information for Comfortis
For cats: The most common adverse reaction recorded in clinical trials was vomiting. Other adverse reactions were: lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin.
The safe use of Comfortis in breeding, pregnant, or lactating cats has not been evaluated. See Comfortis label for complete safety information.
For dogs: The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/ drooling, seizures, incoordination, excessive dilation of pupils, blindness and disorientation. Post-approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions.
Use with caution in breeding females and dogs with pre-existing epilepsy. The safe use of Comfortis in breeding males has not been evaluated. See Comfortis label for complete safety information.
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